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Infection prevention and control is integral to safe, effective and ethical nursing practice. Ensuring the use of infection prevention and control measures is an important component for nursing candidates when they start their clinical practice. This module covers the chain of infection, hand hygiene, use of PPE, healthcare associated infections (HCAIs) and antimicrobial resistance, contributing factors, appropriate steps to break the chain of infection, standard and transmission-based precautions and adopt best practices in collecting, labelling, transporting and reporting on specimens for laboratory analysis.